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What Multivitamin Is Actually Good?

📅 Updated February 2026⏱️ 5 min readNEW

TL;DR

Most multivitamins fail because they use cheap, synthetic forms your body can't absorb. Magnesium oxide, found in most drugstore brands, has an absorption rate of just 4%. To find a good one, you must ignore the marketing and read the "Supplement Facts" panel. Look for methylated B vitamins (methylfolate, not folic acid) and chelated minerals (glycinate, not oxide). If it contains Titanium Dioxide, put it back—it's banned in Europe for DNA damage concerns.

🔑 Key Findings

1

Magnesium oxide (used in Centrum and One A Day) absorbs at ~4%, while magnesium glycinate absorbs 4-5x better.

2

Up to 60% of people have MTHFR gene variants that make synthetic Folic Acid difficult to process.

3

Titanium Dioxide, a common whitener in vitamins, was banned in the EU in 2022 due to genotoxicity.

4

Recent testing showed 27% of multivitamins failed quality standards (too much/little ingredient or didn't break down).

The Short Answer

Most multivitamins are garbage.

If you buy a standard drugstore multivitamin (like Is Centrum Good or Is One A Day Good), you are likely consuming synthetic nutrients your body can't use, combined with fillers that may be harmful. The most egregious example is Magnesium Oxide, which is used in nearly every mass-market multivitamin despite having a paltry 4% absorption rate.

A "good" multivitamin must meet three criteria:

1. Bioavailability: It uses nutrient forms your body actually recognizes (e.g., Methylfolate, not Folic Acid).

2. Safety: It is free of harmful additives like Titanium Dioxide and artificial dyes.

3. Transparency: It lists exact amounts, not "proprietary blends" that hide low dosages.

Why This Matters

Your body isn't a simple bucket you can fill with chemicals. Form matters more than dose. A pill might claim 100% of your Daily Value (DV) for Magnesium, but if it's in the Oxide form, you are effectively getting 4% of that dose. The rest just passes through you (and often causes gas/bloating).

Then there's the genetic factor. Up to 60% of the population has a variation of the MTHFR gene, which makes it difficult to process synthetic Folic Acid. If these people take a standard multivitamin, the unmetabolized folic acid can build up in their blood, potentially masking B12 deficiencies or causing other issues. Folic Acid Vs Methylfolate

Finally, the inactive ingredients are a minefield. Many popular brands use Titanium Dioxide to make their pills look bright white. The European Union banned this additive in 2022 because they could not rule out "genotoxicity" (DNA damage). Yet, it's still in millions of American vitamin bottles. Vitamin Fillers

What's Actually In A Bad Multivitamin

Here is what you will typically find on the label of a mass-market brand like Centrum or One A Day. Bold items are red flags.

  • Calcium Carbonate: Basically chalk. Cheap filler that is poorly absorbed and can cause kidney stones in excess.
  • Magnesium Oxide: The cheapest form of magnesium. Only ~4% is absorbed. The rest acts as a laxative.
  • Dl-Alpha-Tocopherol (Vitamin E): The "dl-" prefix means it is synthetic. It is created from petrochemicals and is roughly 50% less effective than natural Vitamin E (d-alpha).
  • Cyanocobalamin (Vitamin B12): A synthetic form of B12 made with a cyanide molecule. It's cheap and stable, but your body has to detoxify the cyanide to use it. Methylcobalamin is the superior choice. Cyanocobalamin Vs Methylcobalamin
  • Folic Acid: The synthetic form of folate. Difficult for MTHFR mutants (many of us) to process.
  • Titanium Dioxide: Artificial whitener. Banned in the EU.
  • Red 40 / Yellow 6: Artificial food dyes derived from petroleum. Purely cosmetic; zero health benefit.

What to Look For

Use this checklist before you buy any multivitamin.

Green Flags (Buy These):

  • Folate: Listed as "5-MTHF", "L-Methylfolate", or "Methylated Folate".
  • Vitamin B12: Listed as "Methylcobalamin" or "Adenosylcobalamin". Best Form B12
  • Minerals: Listed as "Chelate", "Bisglycinate", or "Citrate" (e.g., Magnesium Bisglycinate).
  • Vitamin E: Listed as "d-Alpha-Tocopherol" (Natural).
  • Vitamin K2: Specifically "MK-7" (Menaquinone-7), which helps direct calcium to bones, not arteries. Vitamin D With K2

Red Flags (Put It Back):

  • Minerals: "Oxide" or "Sulfate" (e.g., Zinc Oxide, Magnesium Oxide).
  • Vitamin E: "dl-Alpha" (Synthetic).
  • Additives: Titanium Dioxide, Hydrogenated Oils, Artificial Colors (Blue 1, Red 40).
  • Proprietary Blends: "Energy Blend" or "Immunity Matrix" without specific milligram amounts for each ingredient.

The Best Options

A good multivitamin costs more because the ingredients cost more to source. You are paying for absorption.

BrandProductVerdictWhy
ThorneBasic Nutrients 2/DayTop Pick. Highly bioavailable forms (5-MTHF, Methyl B12, Bisglycinate minerals). NSF Certified. Is Thorne Multivitamin Good
Pure EncapsulationsO.N.E. MultivitaminExcellent one-a-day option. Hypoallergenic, no fillers, active B vitamins. Is Pure Encapsulations Good
NatureloOne DailyGood budget "whole food" option with natural vitamins and no synthetic fillers.
CentrumAdults / Silver🚫Avoid. Packed with oxides, synthetic E, and Titanium Dioxide. Is Centrum Good
One A DayMen's / Women's🚫Avoid. Cheap synthetic forms, artificial dyes, and poor absorption. Is One A Day Good
SmartyPantsGummies⚠️Acceptable. Uses good forms (Methylfolate), but high sugar and low dosages of some minerals. Are Gummy Vitamins Effective

The Bottom Line

1. Read the "Other Ingredients." If you see Titanium Dioxide or Red 40, put it back. You are supposed to be getting healthier, not eating paint.

2. Check the B12 and Folate. Look for Methylcobalamin and Methylfolate. If a brand spends the money on these, they likely used quality ingredients for the rest of the formula.

3. Skip the Gummies. Unless you physically cannot swallow pills, gummies are usually inferior. They are low in minerals (iron/magnesium taste bad), high in sugar, and unstable. Gummy Vs Pills

FAQ

Is it better to take a multivitamin or individual vitamins?

It depends. If you have a specific deficiency (like Iron or Vitamin D), individual supplements are better because multivitamins rarely contain high enough therapeutic doses. However, a high-quality multi serves as a good "insurance policy" for general nutrient gaps. Is One A Day Good

Why does my multivitamin turn my urine neon yellow?

That is Vitamin B2 (Riboflavin). It is water-soluble and naturally fluorescent. When your body has absorbed what it needs, it excretes the rest. It is harmless and actually a sign the pill dissolved properly.

Are "Whole Food" vitamins better than synthetic?

Usually, yes. Whole food vitamins (like Garden of Life or MegaFood) mimic the complexity of food, which can improve absorption. However, high-quality "synthetic" bio-identical forms (like Methylfolate in Thorne) are just as effective and often more potent. The real enemy is cheap synthetics (folic acid/cyanocobalamin). Synthetic Vs Food Based


References (20)
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  20. 20. rivm.nl

🛒 Product Recommendations

Basic Nutrients 2/Day

Thorne

Top-tier bioavailable forms (methylfolate, bisglycinate minerals) and NSF Certified.

Recommended
O.N.E. Multivitamin

Pure Encapsulations

Excellent one-a-day option with active B12 and no hidden fillers.

Recommended
🚫
Centrum Adult

Centrum

Mostly synthetic forms, oxides, and contains Titanium Dioxide.

Avoid
🚫
One A Day

Bayer

Uses cheap cyanocobalamin, magnesium oxide, and artificial dyes.

Avoid

💡 We don't accept payment for recommendations. Some links may be affiliate links.

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